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Genomic variations and phenotypic diversity are closely linked and form the underlying mechanism for development of many human diseases. This book addresses the methods of detection, analysis, and interpretation of genomic variations in clinically relevant scenarios. If your research or clinical practice involves handling of genomic sequencing data, this book is for you. Topics covered include: methods for identifying genetic diversity, the workflow for analyzing whole exome and whole genome sequencing data, local ancestry deconvolution models, the value of molecular patterns and pattern biomarkers in cancer diagnosis and prognosis, and genotyping and profiling resistance-associated variants of hepatitis C. If your research or clinical practice involves handling of genomic sequencing data, this book is for you.

Medical ethics. --- Biomedical ethics --- Clinical ethics --- Ethics, Medical --- Health care ethics --- Medical care --- Medicine --- Bioethics --- Professional ethics --- Nursing ethics --- Social medicine --- Moral and ethical aspects --- Medical bioinformatics

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This book covers all ethical aspects of introducing novel implants and procedures in neurosurgery in a structured way, addressing the current knowledge gap concerning ethical innovations in neurosurgery. Initially it explores the difficulties involved in defining when a procedure should be considered innovation, research, or care. To this end, it presents not only an overview of current literature, but also data from a recent survey among neurosurgeons in Europe. The book subsequently discusses the ethical issues related to innovation. These include: informed consent (what should a surgeon tell the patient and how should he/she do so), oversight (can any surgeon simply implant a novel spinal device?), the learning curve (when should a surgeon be allowed to perform a novel procedure?), vulnerable patients (how to innovate in the pediatric population or in an emergency setting), and conflicts of interest, as well as the ethics of paying for innovative treatments. In turn, the closing chapters focus on the evaluation of neurosurgical research and innovation. Are cultural changes necessary and how could innovation benefit from (international) collaborations? Given the range of topics addressed, the book offers neurosurgeons, residents, scientists, companies and hospital administrations a valuable guide to introducing novel implants and techniques in neurosurgery. .

Nervous system --- Surgery. --- Nerves --- Neurosurgery --- Surgery --- Neurosurgery. --- Neurology. --- Medical ethics. --- Neurosciences. --- Theory of Medicine/Bioethics. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Biomedical ethics --- Clinical ethics --- Ethics, Medical --- Health care ethics --- Medical care --- Medicine --- Bioethics --- Professional ethics --- Nursing ethics --- Social medicine --- Neuropsychiatry --- Moral and ethical aspects --- Diseases --- Neurology .

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This unique textbook utilizes an integrated, case-based approach to explore how the domains of bioethics, public health and the social sciences impact individual patients and populations. It provides a structured framework suitable for both educators (including course directors and others engaged in curricular design) and for medical and health professions students to use in classroom settings across a range of clinical areas and allied health professions and for independent study. The textbook opens with an introduction, describing the intersection of ethics and public health in clinical practice and the six key themes that inform the book's core learning objectives, followed by a guide to using the book. It then presents 22 case studies that address a broad spectrum of patient populations, clinical settings, and disease pathologies. Each pair of cases shares a core concept in bioethics or public health, from community perspectives and end-of-life care to medical mistakes and stigma and marginalization. They engage learners in rigorous clinical and ethical reasoning by prompting readers to make choices based on available information and then providing additional information to challenge assumptions, simulating clinical decision-making. In addition to providing a unique, detailed clinical scenario, each case is presented in a consistent format, which includes learning objectives, questions and responses for self-directed learning, questions and responses for group discussion, references, and suggested further reading. All cases integrate the six themes of patient- and family-centered care; evidence-based practice; structural competency; biases in decision-making; cultural humility and awareness of the culture of medicine; and justice, social responsibility and advocacy. The final section discusses some challenges to evaluating courses and learning encounters that adopt the cases and includes a model framework for learner assessment.

Medical ethics. --- Theory of Medicine/Bioethics. --- Public Health. --- Biomedical ethics --- Clinical ethics --- Ethics, Medical --- Health care ethics --- Medical care --- Medicine --- Bioethics --- Professional ethics --- Nursing ethics --- Social medicine --- Moral and ethical aspects --- Public health --- Community health --- Health services --- Hygiene, Public --- Hygiene, Social --- Public health services --- Public hygiene --- Social hygiene --- Health --- Human services --- Biosecurity --- Health literacy --- Medicine, Preventive --- National health services --- Sanitation --- Public health.

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Á l’occasion de son vingtième anniversaire, le Centre d’Éthique Médicale a conçu le projet de mettre son parcours et le projet d’une bioéthique clinique qui l’anime, en discussion. La bioéthique a émergé dans une société où la médecine et la santé ont une place centrale et amènent nos contemporains à réinterroger le sens de leur existence. Plusieurs interlocuteurs ont donc été sollicités pour questionner l’apport de la bioéthique à une créativité renouvelée pour un monde habitable demain. Le présent ouvrage croise des regards universitaires mais aussi institutionnels (Commission européenne, OMS). Il met également en perspective la manière dont on peut concevoir la démarche bioéthique en Europe, aux États-Unis ou en Amérique latine. Á l’heure de la globalisation, cette pluralité de regards est indispensable à la perspective d’un monde habitable pour tous et pour chacun.

Medical ethics. --- Bioethics. --- bio-ethiek (medische, biomedische ethiek, bio-ethische aspecten) --- sociologie (sociologische aspecten) --- internationaal perspectief (mondiale invalshoek) --- bioéthique (éthique médicale, biomédicale, aspects bioéthiques) --- sociologie (aspects sociologiques) --- perspective internationale (optique mondiale) --- Bioethics --- Medical ethics --- Biomedical ethics --- Clinical ethics --- Ethics, Medical --- Health care ethics --- Medical care --- Medicine --- Professional ethics --- Nursing ethics --- Social medicine --- Biology --- Life sciences --- Life sciences ethics --- Science --- Moral and ethical aspects --- écologie --- économie --- science --- progrès scientifique --- éthique --- transition

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This volume reviews the application of biochemical and molecular pathologies, which are based on conventional pathomorphology, toxicology, and DNA analysis technologies, not only to autopsies but also to the field of clinical medicine in general. The systematic and integrated use of biochemical, immmunohistochemical, and molecular pathology, toxicology, DNA analysis, and cell culture investigations reinforces the pathophysiological diagnostic criteria in a forensic autopsy for clinical diagnosis. The use of these technologies can help to determine the cause and process of death and characterize the functional pathophysiological changes in the body that occur during the death process. Recently, the systematization of the latest supplemental tests, diagnostic methods, and quality control has allowed us to conduct comprehensive data collection and analysis for a range of diseases. This book presents the latest findings on the pathology of a broad range of human diseases, based on data concerning postmortem biochemistry and molecular biology collected from approximately 1000 people. Further, it puts forward a code of ethics for undertaking pathophysiological research and describes research techniques for uncovering pathophysiological mechanisms. As such, it offers a unique resource for researchers in the field of forensic medicine and pathology, and for clinicians.

Medical jurisprudence. --- Medical ethics. --- Forensic Medicine. --- Biochemistry. --- Forensic medicine. --- Theory of Medicine/Bioethics. --- Medical Biochemistry. --- Forensic Science. --- Biomedical ethics --- Clinical ethics --- Ethics, Medical --- Health care ethics --- Medical care --- Medicine --- Bioethics --- Professional ethics --- Nursing ethics --- Social medicine --- Forensic medicine --- Injuries (Law) --- Jurisprudence, Medical --- Legal medicine --- Forensic sciences --- Medical laws and legislation --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Moral and ethical aspects --- Composition --- Medical biochemistry. --- Forensic science. --- Criminalistics --- Forensic science --- Science --- Criminal investigation --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Bioethics. --- Clinical biochemistry. --- Forensic sciences. --- Life sciences --- Life sciences ethics